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Dragani B, Stenberg G, Melino S, Petruzzelli R, Mannervik B, Aceto A
Data extraction The full texts of the selected articles were reviewed to determine whether articles qualified for inclusion
Expression of adrenocorticotropinreleasing hormone precursor gene in placenta and other nonhypothalamic tissues in man
197 It strengthens intestinal barrier integrity, regulates microbial metabolic activity, suppresses LPS-TLR4-mediated pro-inflammatory signaling, and coordinates FXR- and TGR5-dependent metabolicinflammatory pathways, forming a protective network across metabolic, immune, and barrier functions
The release of these metabolites can disrupt mitochondrial electron transport complexes, leading to increased production of ROS as a result of premature electron reactions with molecular oxygen [19]
Nature 2011 472(7341):57 - 63 K
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