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You would never know by looking at it, because the solution might still appear clear, but the biological activity would be degraded

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Antidepressant Effects In a study conducted by Sikiric et al

Compared with normal renal function, the estimated ratio of the mean AUC 0 was 1.23 (90% confidence interval [CI], 0.911.66) in mild impairment, 1.18 (0.871.59) in moderate impairment and 1.21 (0.871.68) in severe impairment