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3.2 Gut microbiota alterations in OA 3.2.1 Gut microbial dysbiosis in OA Recent years have seen many novel studies unveiling the important role of gut microbiota dysbiosis in OA pathogenesis, with strong evidence for the gut-joint axis hypothesis of OA

This is a feedback loop involving the hypothalamus (releasing GnRH), the pituitary (releasing LH and FSH), and the gonads (producing testosterone)

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For dissocated strial cultures, the stria vascularis is pulled off the lateral wall and collected separately