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These exposures act via a mechanism involving hormonal dysregulation, oxidative stress buildup, DNA damage, and epigenetic alterations

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Cold Spring Harb Perspect Biol (2014) 6(10):a016295a016295

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Semaglutide (Wegovy) received FDA accelerated approval specifically for adults with non-cirrhotic MASH and moderate to advanced liver fibrosis (F2F3 fibrosis stages)

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Beyond iron handling, NRF2 modulates the GSH antioxidant system by inducing the expression of enzymes required for GSH biosynthesis, such as glutamatecysteine ligase catalytic and modifier subunits (GCLC/GCLM), glutathione synthase (GSS), and the cystine/glutamate antiporter subunit SLC7A11 [114]

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