Preclinical models demonstrate that these compounds reduce reactive oxygen species, stabilize mitochondrial membrane potential, enhance mitophagy, and activate NRF2 dependent transcription, which translates into attenuation of ASD like behaviors in VPA, propionic acid, maternal immune activation, and BTBR paradigms (De Mattos et al., 2020
Its mode of action includes
It's absorbed through the nasal mucosa for good bioavailability
When SAH accumulates, it inhibits many methyltransferases and can reduce effective methylation even when folate, methionine or SAM are available
2-(2-Cholesteroxyethoxyl)ethyl-3-S-glutathionylpropionate (COXP) for brain-targeting liposomes
This reduction in oxygen delivery can cause you and your family members to feel unusually tired or weak