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Tagliamonte A, DeMontis MG, Olianas M, Onali PL, Gessa GL

This is not typical of incretin-based therapies and appears to be unique to retatrutide, possibly related to the glucagon receptor component

and other sources of bias (i.e., early trial discontinuation)

Your doctor may suggest different medications, lifestyle changes, or dietary adjustments that are safer during pregnancy

Sean Hashmi, MD: My pleasure

The mechanism has been associated with enhanced blood flow to active musculature, however, it might be more far-reaching as either ammonia homeostasis could be improved, or ATP production could be increased via greater availability of malate