A 2026 systematic review confirmed that L-Citrulline, especially when combined with antioxidants, increases nitric oxide bioavailability and reduces oxidative stress in endothelial cells
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The German BfArM and equivalent agencies (ANSM in France, AEMPS in Spain, AIFA in Italy, URPL in Poland) treat unauthorized human use of these compounds as outside the scope of the marketing authorization regime entirely
Si bien, este meta-anlisis describe un efecto positivo global de esta familia de frmacos, an no han surgido estudios Head-to-Headentre estos frmacos para seguridad cardiovascular, donde la poblacin estudiada sea comparable, por lo que una de los principales objetivos en los prximos aos es la realizacin de estos anlisis para conocer especficamente el efecto de individual de los GLP1-RA en los eventos cardiovasculares 142
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