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All participants received counseling for diet (aiming for a reduction of approximately 500 kcal per day) and physical activity (with a recommendation of at least 150 minutes of exercise per week)

The half-life remains about one week, and the clearance window is still about five to seven weeks for most patients

However, distinguishing between medication-related gastrointestinal symptoms and pre-existing post-surgical digestive changes requires careful monitoring during treatment initiation

While taking semaglutide, potential side effects such as nausea, diarrhea, and headaches might occur

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Regular reviews every 36 months assessing glycaemic control, weight, and tolerability are recommended, with more frequent monitoring for autoimmune disease patients