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This incretin effect is considerably attenuated in people with type 2 diabetes (see Figure 1), a loss that is even considered an early indicator of the disease, but it was observed that this deficit could be completely corrected by the continuous infusion of GLP-1 to diabetic patients

BMJ 384, e076410

The other long-term consideration is dose stability

Week 1-4: Starting the Journey In the initial weeks, weight loss may be slow

Some people are more sensitive to these changes, which can contribute to the side effects

If nausea is severe or persists, talk to your doctor to change the medication or explore alternative treatments