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The phrase per night in this articles title reflects how people search, so it deserves a direct answer rather than a dodge: the research does not establish a per-night timing protocol, and parts of it actively undercut the premise

Several GLP-1s are beneficial to heart health, but some patients report a slightly elevated heart rate while on them

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Tao CL, Liu YT, Sun R, Zhang B, Qi L, Shivakoti S, et al

Lifestyle intervention, including dietary modification and increased physical activity, remains the cornerstone of obesity management alongside any pharmacotherapy