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In research models with elevated NNMT activity, this methylation reaction has been reported to deplete cellular SAM pools and reduce NAD+ availability

Despite preliminary evidence suggesting that KD is safe and effective in individual cases, the available data is not representative and remains insufficient

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In SETD1B knockout cells, CHAC1 is not upregulated, preventing GSH depletion and conferring resistance to mycolactone-induced cytotoxicity (Figure 2) (Frster et al., 2020)