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While adequately powered for the primary outcome, 1415 patients per group is relatively small

The absence of apoptosis in the PBMC from patients with Graves hyperthyroidism may be attributed to alterations in apoptotic signalling pathways or a lower intensity of Fas expression in these cells.25 Conversely, increased apoptosis has been found in lymphoid cell lines or in peripheral blood T lymphocytes treated in vitro with thyroid hormones for different times.26,27 Furthermore, increased apoptosis was found in PBMC from patients with untreated Graves disease after 24h of in vitro culture.27 Hara et al

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10.1038/s41392-021-00687-0 Signal Transduct Target Ther