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When gallstones obstruct the bile passage from the gallbladder to the small intestine, they can result in nausea, jaundice , and pain in the abdomen

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Furthermore, a protein-truncating variant in HSD17B13 has been associated with NASH and fibrosis but not with steatosis 21

Estimates suggest that tobacco use causes about 80,000 cases of gastric cancer annually (11% of all estimated cases) ( 4 Oxidative stress in gastric cancer 4.1 Gastric carcinogenesis Under oxidative stress, increased ROS in cells may harm tissues and trigger carcinogenesis, especially in the gastrointestinal system ( Figure 3 )

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