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History of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 represents absolute contraindications

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Like any new drug or treatment, mandating new coverage will drive up costs for everyone with private insurance, for employers who provide benefits, and for taxpayers who foot the bill for state-sponsored benefits

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This prolonged exposure does not proportionally increase therapeutic benefit because tissue binding sites saturate, but it does increase total copper exposure