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Controls were set up using comparable reaction conditions with shelterin and 300 M of the inactive control compound 60 or TRF1 only (without ligand)

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Researchers are particularly interested in its behavior under metabolic stress, where mitochondrial-derived peptides appear to play a regulatory role in how cells adapt energy production to changing demands

It is important to note that if ED develops or worsens during GLP-1 therapy, this is more likely related to the underlying conditions being treated (diabetes, obesity, cardiovascular disease) or other concurrent factors rather than the medication itself

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The mechanisms underlying hair loss during GLP-1 therapy likely involve multiple contributing factors rather than a single direct drug effect