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[DOI] [PubMed] [Google Scholar] 62.Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, Pais P, et al

Measuring body composition (fat versus lean mass) should become routine in the management of patients on GLP-1 medications. The Takeaway While GLP-1 medications are effective for weight loss, rapid weight reduction can lead to significant loss of fat-free mass, including muscle

Semaglutide in Type 2 Diabetes SURPASS-2 (N=1,879) compared tirzepatide 5, 10, and 15 mg to semaglutide 1 mg over 40 weeks [29]

Reduced iHSP72 levels in skeletal muscle and other insulin-responsive tissues are strongly associated with insulin resistance, a defining feature of T2DM

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p=0.0002)