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The work was funded by the National Institutes of Health (grant K99HL130523) and the Sarnoff Cardiovascular Research Foundation

Many experimental studies have shown that female mice are less susceptible to APAP hepatotoxicity than males and that the sex differences are substantial [17,18,35]

There were multiple reported AE and management strategies that were not captured within the ASGE criteria

Funding This work was financially supported by the National Key R&D Program of China to D.Z

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The lack of data had previously led societies to rely on expert opinion for guidance