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We are the first meta-analysis comparing the different administration routes of vitamin B12, and the first meta-analysis includes the SL route of administration in the analysis

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Low Levels of Serum Total Vitamin B12 Are Associated with Worse Metabolic Phenotype in a Large Population of Children, Adolescents and Young Adults, from Underweight to Severe Obesity

That selectivity matters in research for two reasons: Cleaner interpretation: If a compound pushes fewer off-target endocrine pathways, observed outcomes are easier to connect to the intended mechanism