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Abbreviations CSCs: Cancer stem cells EMT: Epithelial-mesenchymal transition TME: Tumor microenvironment TAM: Tumor-associated macrophages CAF: Cancer-associated fibroblasts EC: Endothelial cells TICs: Tumor-initiating cells AML: Myeloid leukemia SCID: Severe combined immune-deficient SOX2: Sex-determining region Y HMG-box 2 ALDH1A1: Aldehyde dehydrogenases 1A1 ABCG2: ATP-binding cassette sub-family G member 2 JAK/STAT: Janus kinase /signal transducer and activator of transcription TCA: Tricarboxylic acid cycle OXPHOS: Oxidative phosphorylation PDK: Pyruvate dehydrogenase kinase CRC: Colorectal cancer RNAi: RNA interference PFKFB4: 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PKM2: Pyruvate kinase M2 hypotype HIF-1: Hypoxia-inducible factor-1 NADH: Nicotinamide adenine dinucleotide iPS: Pluripotent stem cells G6P: Glucose-6-phosphate GLUT-1: Glucose transporter 1 HK-1: Hexokinase 1 ROS: Reactive oxygen species OCR: Oxygen consumption rate DRP1: Mitochondrial dynamics PGC1: Peroxisome proliferator-activated receptor-gamma co-activator one alpha MUFAs: Unsaturated lipids like monounsaturated FAs TKI: Tyrosine kinase inhibitor FASN: Fatty acid synthase HCC: Hepatocellular carcinoma RHAMM: Hyaluronic acid (HA), hyaluronan-mediated motility ECM: Extracellular matrix mTOR: Mammalian target of rapamycin PI3K: Phosphoinositide 3-kinases MAPK: Mitogen-activated protein kinase ERK: Extracellular signal-regulated kinase TGF-: Transforming growth factor beta FSS: Fluid shear stress Dlx-2: Distal-less homeobox 2 ZEB: Zinc finger E-box-binding homeobox MSC: Mesenchymal stem cells BMDCs: Bone marrow-derived cells PGI: Phosphoglucose isomerase AMF: Autocrine motility factor PKM2: Pyruvate kinase isomerase M2 LDHA: Lactate dehydrogenase A FGF: Fibroblast growth factor HGF: Hepatocyte growth factor NK: Natural killer DCs: Dendritic cells MDSC: Myeloid-derived suppressor cells VEGF: Vascular endothelial growth factor HIF-1: Hypoxia-inducible factor-1 MMPs: Matrix metalloproteinases NF-B: Nuclear factor-kappa B IGF1: Insulin-like growth Factor 1 Receptor CAEC: Cancer-associated endothelial cells TNF-: Tumor necrosis factor-alpha TIL: Tumor-infiltrating lymphocytes 5-FU: 5-fluorouracil HDGF: Anti-hepatoma-derived growth factor FAP: Fibroblast activation protein References Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A