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Tentolouris A, Tentolouris N, Eleftheriadou I, Jude EB

Mutant p53 inhibits autophagy by decreasing the mRNA or protein levels of Sestrins, preventing the activation of the AMPK signaling pathway and the formation of autophagic vesicles

Prescribing authority was relatively concentrated, and decision-making followed established clinical algorithms

Future studies should verify biochemical repletion, standardize dosing and timing, and integrate biomarker-anchored, systems-level endpoints