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Although both classes of drug have shown significant benefit versus placebo control in phase 3 clinical trials, the residual risk remains high after treatment with either of these drug classes in CKD and T2D (Table 1) [12,13,14,15,16]
Am Fam Physician 2006
The majority of these publications originate from Asia, North America, and Europe, including countries such as China, the United States, and Italy
As the available evidence is still limited, this review focuses on these diseases while placing particular emphasis on the molecular mechanismssuch as modulation of inflammatory pathways, promotion of weight loss, strengthening of antioxidant defense against reactive oxygen species (ROS), and alterations in the gut microbiotawhich may provide broader insights into the potential effects of KD on skin health (14, 1820)
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