Drawbacks of Intermittent Fasting As a natural lifestyle change, intermittent fasting can be a great strategy for many people, but that doesnt mean it comes without any downsides
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In cells, HDAC1 and HDAC3 appear to dominate histone delactylation, as sirtuin inhibition (nicotinamide) has little impact on global histone lactylation, supporting a key role for nuclear HDAC1/2/3 in removing lactyl marks on chromatin [61, 62]
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