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Published mouse studies did not report overt toxicity, liver-enzyme issues, or sickness-related weight loss at 25-50 mg/kg IP for up to 8 weeks

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AHK-Cu has been studied in this context for its possible contribution to enhancing VEGF signaling, which may in turn support fibroblast and endothelial cell activity

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Emerging research explores NNMT inhibitors with enhanced selectivity, longer half-lives (potentially enabling less frequent dosing), and tissue-specific effects