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PDI has two active sites, both of which are characterized by the presence of a CGHC motif, which either forms a disulphide for the enzyme to become active as an oxidase, or a dithiol for the enzyme to act as an isomerase

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Especially for those who suffer from stomach difficulties such as pernicious anemia or inflammatory bowel disease, B12 injections are a preferred choice as they bypass potential absorption issues

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Nature (2014) 505:55963