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This results in uncoating and endosomal escape of the viral load, thus enabling successful infection of the FcRn-expressing host cell [378]

Approximately 3% of women and 0.5% of men will develop the disease during their lifetime.1 Thyroid hormones regulate many physiological functions, increase cellular metabolism and mitochondrial activity in most tissues

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Pain and swelling in the hands and feet may appear as early as six months of age (dactylitis)