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It is an anatomically small brain region that contains widespread projections to multiple brain regions, thus activating this single site has the potential to result in widespread brain activation [93]

1a), we prioritized EMC3, which enabled the purification of ER with markedly reduced contamination from other organelles (Extended Data Fig

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The prevalence of this condition varies by gender, with an estimated 8.1% of women and 5.4% of men over the age of 65 experiencing some form of dementia, nearly 70% of which corresponds to Alzheimers disease (AD) ( The etiology of AD is complex and multifactorial, characterized by progressive neuronal aging, synaptic loss, and dysfunction of neural networks ( Additionally, the hyperphosphorylation of tau protein disrupts its binding to neuronal microtubules