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Database resources of the National Center for Biotechnology Information

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Some medical conditions or medications can make it less effective or potentially unsafe

Restoration effect If someone loses weight because theyre unwellpoor appetite and low intake due to a deficiencythen treating that deficiency restores appetite and energy and weight may return

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However, IGF-1 DES is not without concernshypoglycemia risk, unknown long-term local tissue effects, and the fundamental question of whether truly site-specific muscle growth is achievable or desirable