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The addition of GIP to GLP-1 (as in tirzepatide) added approximately 57% more weight loss compared to GLP-1 alone

Acne from TRT is generally considered a manageable side effect rather than a reason to discontinue therapy

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O-GlcNAcylation turnover is controlled by a single pair of enzymes: O-linked N -acetylglucosaminyltransferase (O-GlcNAc transferase or OGT) adds the GlcNAc motif to proteins, and O-linked N -acetyl -d-glucosaminidase (O-GlcNAcase or OGA) removes it