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Recent evidence from the STEP-HFpEF and STEP-HFpEF-DM trials provides the first robust data supporting the efficacy of GLP-1 RAs, specifically semaglutide, in improving the quality of life in obese patients with HFpEF

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Using semaglutide after the expiration date may result in reduced potency, meaning your dose may not produce the intended appetite suppression or metabolic effects

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Risk factors include age over 50, male gender, white ethnicity, obesity, smoking, and family history of esophageal cancer