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its influence on mood regulation appears secondary to improvements in neurovascular coupling, synaptic microenvironment stabilization, and antioxidant protection that preserve neurotransmitter signaling integrity rather than directly increasing monoamine levels (99, 100)

Extended data Extended Data Fig

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Cell 65 , 10441055.e5 (2017)

However, everyone's biochemistry is unique

This mechanism of action is discussed in more detail in the discussion of Na + channel blockers in Chapter 11 and is also responsible for cardiac toxicity of local anesthetics