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Abstract Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has transformed the treatment landscape for type 2 diabetes and obesity due to its robust efficacy and wide-ranging therapeutic benefits

In patients with chronic kidney disease (CKD) and type 2 diabetes, the dosage is increased to a maintenance dosage of 1 mg once weekly after an initial dosage of 0.5 mg once weekly for at least 4 weeks

Expensive: Ozempic can be expensive, with current prices hovering around $1,000 per month for the medication

GLP-1 medications create a series of events: Your pancreas releases more insulin Glucagon (what triggers blood sugar release) is blocked Gastric emptying slows down (so you feel full longer) When you feel satisfied, youre less likely to overeat, and you may find it easier to stick with your daily calorie budget

Patients with diabetes who initiate semaglutide therapy may already be at risk for diabetic peripheral neuropathy, a common complication of prolonged hyperglycemia that can present with various pain syndromes including allodynia