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The sequence begins with ERmitochondria calcium maladaptation, continues through redox amplification and lysosomal-autophagic failure, and then extends to the cytoskeletal, plasma-membrane, nuclear, lipid, peroxisomal, and secretory consequences of bioenergetic collapse

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[3] There seems to be a strong stress-related component

4 Dysbiosis, or alterations in the gut microbiota, have been associated with obesity, insulin resistance, and diabetes

Therefore, the introduction of artificial intelligence-powered computer-aided drug design in this field may be an effective means to rapidly advance research and development