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Indeed, GDH1 knockdown reduced while exogenous -KG supplementation elevated intracellular -KG abundance (Extended Data Fig

It was recently shown that antioxidants can prevent loss of HSCs self-renewal potential in several contexts, such as aging or after exposure to low doses of irradiation, suggesting that antioxidants can be used to maintain HSCs functional properties upon culture-induced stress [20, 21]

The compositions of these media are listed in Supplementary Table 2

A landmark brain imaging study using proton magnetic resonance spectroscopy (1H MRS) revealed a staggering 36% decrease in cortical glutathione levels in the brains of ME/CFS patients compared to healthy controls

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