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Data availability The datasets generated and analyzed during this study are included in the Supplementary files

In patients with T2DM who do not have atherosclerotic cardiovascular disease (ASCVD)/indicators of high-risk, HF, or CKD and who need to minimize hypoglycemia and/or promote weight loss, GLP-1 RAs are generally recommended as a second or third-line option as add-on to metformin therapy

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Additionally, the fed state typical of evening hours may reduce absorption efficiency compared to morning fasted dosing

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