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& Pappenheimer, J

The CO 2 produced by the IDH3 reaction is from the original C-1 carbon of the oxaloacetate used in the citrate synthase reaction

Increase maintenance frequency from twice weekly to three times weekly (e.g., Monday, Wednesday, Friday) or increase the dose from 0.5mg to 1mg per injection

Clinical evidence suggests that stopping the medication abruptly can trigger a significant rebound effect

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This extraordinary potency difference stems from Dihexas mechanism as an HGF mimetic binding to c-Met receptors, which triggers intracellular signaling cascades distinct from BDNFs TrkB receptor pathway