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Interestingly, the gut metabolic module aspartate degradation I, which converts L-aspartate to oxaloacetate by aspartate aminotransferase, was elevated in SAD patients and the authors hypothesized that bacterial aspartate aminotransferase enzyme activity may represent a link between gut microbiome function and the tryptophan-kynurenine pathway, a key physiological system in psychiatric disorders (Butler et al., 2023)

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Additional references were also obtained from the references cited by a recent relevant meta-analysis ( Inclusion criteria RCTs were included if the worst OIPN grade on treatment in adult CRC patients was evaluated using the CTCAE scale and patients were randomised to a pharmacological agent or traditional herbal medicine being tested as a preventative treatment for OPIN

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