doi: 10.1007/s40265-018-0946-y
Similar unpublished preclinical data on file at Merck has been summarized (35)
8.5 Geriatric Use In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy
The most frequently reported risks include injection-site pain, redness, or swelling
The formulation does not contain therapeutic agents and is designed exclusively for reconstituting, diluting, or dissolving compatible compounds prior to research use
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