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When caloric intake is substantially reduceda common occurrence given semaglutide's potent effects on appetite and satietythe body shifts from primarily using glucose for energy to breaking down stored fat

Vaughn DJ, Bellmunt J, and Fradet Y, et al (2018) Health-related quality-of-life analysis from KEYNOTE-045: a phase III study of pembrolizumab versus chemotherapy for previously treated advanced urothelial cancer J Clin Oncol 36 (16) 15791587 PMID: 29590008 10

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