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Further research indicates that, in HG-induced rat retinal Mller cell (rMC-1) and db/db mouse models, Panax ginseng saponin R1 (NGR1) increased the levels of PINK1 and Parkin in the retina as well as in rMC-1 cells of db/db mice, increased the LC3-II/LC3-I ratio, and decreased the levels of p62/SQSTM1, however, knockdown of PINK1 eliminated the protective effect of NGR1, inferring that NGR1 prevents DR through PINK1-dependent enhancement of mitophagy [158]

For instance, betaine also was proved as an antitumor component in beetroot despite its activity being lower than betanin (Lee et al., 2014)

Its pathogenesis is closely related to the imbalance of glycolipid metabolism