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As TFAM does not always exhibit parallel with the mtDNA copy number, TFAM should be used judiciously as a marker of mitochondrial biogenesis ( Overview of the Mitophagy Autophagy, meaning self-eating in Greek, is a process by which portions of cytoplasm, such as the organelles and protein aggregates, are sequestered and subsequently delivered to lysosomes for degradation (Nakatogawa et al., 2009)

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