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The GLP-1 RA and Its Relationship with Brain Insulin Resistance Brain IR can be defined as the failure of brain cells to respond to insulin, and the lack of response may be due to the downregulation of insulin receptors, an inability of insulin receptors to bind insulin, or faulty activation of the insulin signaling cascade

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This potential action appears linked to VEGFR2-related pathways, which are involved in nitric oxide signaling and endothelial cell activity