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In clinical practice, the high-confidence indications are narrower and more specific than the internet suggests

In adults, deficiency may cause megaloblastic anaemia , leading to weakness and fatigue

For urgent but non-emergency concerns, contact NHS 111 or attend an A&E department, and report any suspected adverse reactions to the MHRA via the Yellow Card Scheme at yellowcard.mhra.gov.uk

[1] [2] While high-dose oral B12 supplements can be effective through passive diffusion, they are not routinely recommended for pernicious anaemia management in UK practice

Insufficient intrinsic factor production, common in older adults due to age-related absorption decline, can also lead to deficiency

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