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In the absence of coenzyme B12, tetrahydrofolate cannot be regenerated from its inactive storage form, 5-methyl tetrahydrofolate, resulting in functional folate deficiency

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AOD-9604 is administered subcutaneously with a half-life of approximately 23 hours in humans (measured in Phase 2 trials), also requiring daily dosing

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Yes, pregnant women need more vitamin B12

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