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Under normal physiologic conditions, intracellular GSH concentrations of neurons are 250- to 500-fold higher than in the CSF, 17 thus limiting the utility of CSF to serve as a biomarker of cellular GSH status

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All procedures were conducted under aseptic conditions

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When this internal timing system is disruptedwhether by shift work, jet lag, or lifestyle factorsit can lead to difficulties in falling asleep or staying awake at the desired times