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Estrogen-driven angiogenesis is associated with the proliferative phase, and progesterone-driven vascular maturation occurs in the secretory phase

This observation of drug resistance driven by clonal expansion through intra-tumoral heterogeneity underscores the current limitations in our understanding of the specific stages of ovarian cancer progression and the identification of optimal cellular (e.g., cancer stem cells) or genetic targets for effective gene therapy

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*Correspondence: Zhenjie Liu, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Biosafety and Biosecurity, a section of the journal Frontiers in Bioengineering and Biotechnology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers