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Approximately 12.0% of participants on the highest dose became completely pain-free, demonstrating how extreme weight loss can radically alter the clinical course of degenerative joint disease

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The intensive lifestyle intervention group achieved greater weight loss (6.0% vs 3.5%) and reductions in glycated haemoglobin (HbA 1c ) as well as in all traditional CVD risk factors, except for LDL-cholesterol