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Beyond its initial recognition as a neuroprotective agent, Humanin has demonstrated cytoprotective effects in various cell types, including cardiomyocytes, neurons, and endothelial cells (Chai et al., 2019)

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The sham procedure is similar and consists of laparotomy without renal pedicle clamping

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Nanomaterials 10(12):2368 Jones IA, Togashi R, Wilson ML, Heckmann N, Vangsness CT Jr (2019) Intra-articular treatment options for knee osteoarthritis