Taken together, these observations underscore how astrocytic metabolic and transporter dysfunctions underlie synaptic dysregulation and BBB disturbances in neurodegenerative diseases
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As a general procedure, the investigators directly performing the experimental procedures were not blinded to the group allocation, but data analyses by senior authors were largely conducted independently to avoid potential bias
PKLR is an enzyme responsible for catalyzing the conversion of phosphoenolpyruvate and adenosine triphosphate (ATP) to pyruvate and ATP in glycolysis 45
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Why does the delivery method flip the comparison