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Notably, longitudinal and prodromal-stage studies suggest that these compositional differences may precede the onset of motor symptoms, supporting a potential contributory role rather than a purely secondary effect [36]

Collectively, these data uncovered a severe mitochondrial OxPhos dysfunction in pre-symptomatic Trkb Penk -KO mice, consistent with the RNA sequencing (RNA-seq) data and GSEA pathway analysis

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