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AOD-9604 is administered subcutaneously with a half-life of approximately 23 hours in humans (measured in Phase 2 trials), also requiring daily dosing

Preclinical research models have explored its interactions with angiogenic signaling, tissue response pathways, and receptor-associated biological mechanisms in small-animal and in-vitro studies

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Other conditions that make Vitamin B12 absorption more difficult are: Weight loss surgery or another operation that removed part of your stomach Heavy drinking Taking acid-reducing medication for a long time Certain health issues may also lead to the development of vitamin B12 deficiency such as atrophic gastritis, pernicious anemia, Crohns disease, celiac disease, immune system disorders, Graves disease and lupus